Prevalence and Clinicopathological Characteristics of BRAF Mutations in Chinese Patients with Lung Adenocarcinoma

摘要: This study was designed to identify the prevalence of BRAF mutations in Chinese patients with lung adenocarcinoma, and reveal association between clinicopathological characteristics these patients. From October 2007 February 2013, newly diagnosed primary adenocarcinoma were detected for BRAF, EGFR, KRAS, HER2 ALK. Clinicopathological characteristics, including sex, age, TNM stage, tumor differentiation, smoking status, histological subtypes, survival information analyzed. Of 1358 20 harboring mutations, five V600E 15 non-V600E mutations. Among these, N581I G593S reported. associated status (odds ratio 3.28; 95 % CI 1.33–8.08; p = 0.008). In less than 60 years tended have poor differentiation samples (70.0 vs. 35.1 %; p = 0.014), more likely relapse (70 28 %; A significant difference found relapse-free (RFS) other but not overall survival. The approximately 1.5 %. frequent current smokers. Patients had a higher rate recurrence worse RFS compared