Multimodality correlative study of canine brain tumors. Proton magnetic resonance spectroscopy, positron emission tomography, and histology.

摘要: RATIONALE AND OBJECTIVES Structural/functional relationships in an induced canine brain tumor were studied using proton-magnetic resonance spectroscopy (1H-MRS), positron emission tomography (PET), and histology. METHODS Proton-MRS PET data of implanted tumors correlated with quantitative analysis the tissue composition within MRS regions interest (ROIs). Linear regression was employed to correlate 1H-MRS percent total lesion (comprising plus associated pathology ie, edema, cysts, hemorrhage, inflammation) ROI. RESULTS Using 1H-MRS, N-acetyl aspartate concentrations indirectly amount (P = .058), as well .032) Total creatine ROI or .08. CONCLUSIONS The complementary respect suggesting anaerobic glucose metabolism for tumor. Unlike other tumors, no increase choline noted