Experimental research Protective effect of melatonin against zonisamide-induced reproductive disorders in male rats

摘要: INTRODUCTION Zonisamide (ZNS) is a modern antiepileptic drug (AED) that distinguished from other AEDs by its unique structure and broad mechanistic profile. The pineal hormone melatonin involved in the regulation of reproductive function, including timing luteinizing (LH) surge. aim present work was to study protective effect against potential suppression impact ZNS on activity. MATERIAL AND METHODS Ninety adult albino male rats were allocated several groups treated with (10 mg/kg BW), (10, 20 50 BW) 10 plus or BW, respectively). Reproductive hormones (testosterone, LH follicle-stimulating (FSH)) levels measured animal serum. Sperm abnormalities DNA fragmentation testis tissues as well expression alteration reproductive-related genes analyzed. RESULTS results revealed decreased serum free testosterone, LH, FSH their encoding rats. In addition, treatment increased sperm inducible nitric oxide synthase (iNOS) GABA level liver tissues. However, supplementation inhibited negative symptoms which it ZNS-treated Moreover, abnormalities, fragmentation, iNOS activity CONCLUSIONS data obtained this suggest administration confers protection toxicity inflicted ZNS, support contention achieved ability scavenger for radicals generated ZNS.