Coxsackie B1 virus-induced murine myositis: relationship of disease severity to virus dose and antiviral antibody response.

摘要: Inoculation of Coxsackie B1 virus (CB1) in newborn CD1 Swiss mice induces a chronic myositis proximal hindlimb muscles (CB1 myositis). To study the possible role dose, and antiviral antibodies development CB1 myositis, we infected groups with six doses, ranging from 30 to 10,000 plaque forming units (pfu); after 4 8 weeks determined morbidity antibody titer, quantified histopathological changes. At weeks, mononuclear cell infiltration differed significantly for various groups, most prominent changes 300 pfu animals. diseased animals had higher titers than clinically unaffected animals, at myopathic infiltrative correlated positively serum titer. Our data indicate that dose plays pathogenic they suggest further on humoral immune mechanisms early phase myositis.