作者: Kazumasu Sasaki , Shuzo Yamamoto , Tatsushi Mutoh
DOI: 10.1371/JOURNAL.PONE.0241234
关键词:
摘要: Objective Optimizing cardiac stroke volume during high-risk surgical anesthesia is of particular interest with regard to a therapeutic target reduce the incidence postoperative complications. However, intensive fluid management in critically ill small animals pulmonary hypertension (PH) has been empirically performed, and thus it can be challenging. Stroke variation (SVV) used as dynamic preload predictor responsiveness. We hypothesized that if SVV exhibited robust reliability setting hemodynamically unstable condition, would provide more precise information on resuscitation translate into veterinary anesthesia. Thus aim this study was investigate utility measured by electrical velocimetry (EV) method for predicting responsiveness dogs PH. Methods Sixteen undergoing emergency abdominal surgery diagnosed PH secondary myxomatous mitral valve disease (MMVD) preoperative transthoracic echocardiogram were included. Dogs randomly assigned 2 groups without inotropic support dobutamine. Hemodynamic measurements including derived from EV device performed under general before (baseline) after (fluid challenge colloid solution defined SV increase ≥ 10%). Results In both groups, elevated significantly compared baseline. dobutamine infused group, values decreased (P < 0.05) greater number responders than saline control group 0.01). Receiver operating curve analysis confirmed high positive predictive value infusion 0.05; cut-off 15%; specificity 90%, sensitivity 82%). Conclusions Noninvasive monitoring may useful prediction left-sided heart failure-related This normalization indices, which could achieved precisely support, prevent further detrimental consequence loading.