RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity

摘要: Summary Asp-Glu-Ala-Asp (DEAD)-box polypeptide 3, or DDX3, belongs to the DEAD-box family of ATP-dependent RNA helicases and is known play different roles in metabolism ranging from transcription nuclear export, translation, assembly stress granules. In addition, there growing evidence that DDX3 a component innate immune response against viral infections. As such, has been shown both upstream downstream I-kappa beta kinase e (IKKe)/TANK-binding 1, leading IFN-β production. Interestingly, several viruses, including human threats such as HIV-1 hepatitis C virus, hijack accomplish various steps their replication cycles. Thus, it seems viruses have evolved exploit DDX3's functions while threatening response. Understanding this interesting dichotomy function will help us not only improve our knowledge virus–host interactions but also develop novel antiviral drugs targeting multifaceted replication. Copyright © 2015 John Wiley & Sons, Ltd.