Epidermal differentiation complex protein involucrin is down-regulated in eosinophilic esophagitis

摘要: Epidermal differential complex (EDC) proteins, such as filaggrin, involucrin, and loricrin, play key roles to protect the mucosal surface against invading pathogens. Eosinophilic esophagitis (EoE) is an allergic gastrointestinal disease that features eosinophilic infiltration of esophageal mucosa, though function EDC proteins in its pathogenesis remains unknown. The aim this study was investigate possible differences protein expression epithelium esophagus, pharynx, tongue. Furthermore, we examined specimens obtained from patients with EoE. For evaluating different locations, enrolled 72 who underwent surgical resection for esophageal, pharyngeal, or tongue squamous cell carcinoma. Pathological samples were used analysis by immunohistochemistry. In addition, 10 EoE 11 healthy subjects, compared epithelial proteins. tongue, presence confirmed immunohistochemistry findings, patterns notably comparison epidermis samples. patients, involucrin dramatically down-regulated whereas down-regulation filaggrin loricrin did not reach a statistically significant level. clearly detected pharyngoesophageal samples, while alone markedly reduced