Prospective randomised trial of metronidazole versus vancomycin for clostridium-difficile-associated diarrhoea and colitis

摘要: Abstract 101 patients with Clostridium-difficile -associated diarrhoea or colitis were prospectively randomised to 10-day oral courses of metronidazole, 250 mg four times a day, vancomycin, 500 day. 7 did not complete the protocol and dropped from analysis. Pseudomembranous (PMC) was diagnosed after endoscopy in 33 patients. Of remaining without PMC, 38 had both C difficile culture cytotoxin 23 only evidence difficile. 52 evaluable received vancomycin 42 metronidazole. There two treatment failures metronidazole none (p = 0·20); relapses versus six 0·17). Treatment 1 patient each group discontinued because drug intolerance. Response relapse rates PMC no different those Pharmacy cost for dosage used $387.48 $520.00 $11.84 Metronidazole have equivalent efficacy are tolerated similar extent by C-difficile -related colitis, but is considerably more economical.