Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease.

摘要: Chronic kidney disease (CKD) is a growing public health problem and end stage renal (ESRD) represents large human economic burden. It important to identify patients at high risk of ESRD. In order determine whether Doppler resistive index (RI) may discriminate those patients, we analyzed RI was associated with identified prognosis factors CKD, in particular histological findings, outcome. measured the 48 hours before biopsy 58 CKD patients. Clinical biological data were collected prospectively inclusion. Arteriosclerosis, interstitial fibrosis glomerulosclerosis quantitatively assessed on blinded fashion. MDRD eGFR 18 months for 35 (60%) Renal function decline defined as decrease from baseline least 5 mL/min/ 1.73 m2/year or need chronic replacement therapy. Pearson’s correlation, Mann–Whitney Chi-square tests used analysis quantitative qualitative variables respectively. Kaplan Meier realized survival according value using log-rank test. Multiple logistic regression performed including p 20% (p = 0.014) 0.0023) had higher RI. Patients ≥ 0.65 poorer outcome than < 0.0005). multiple regression, RI≥0.65 accelerated independently proteinuria/creatininuria ratio (OR=13.04 [1.984-85.727], 0.0075). Sensitivity, specificity, predictive positive negative values respectively 77%, 86%, 71% 82%. Our results suggest that severe arteriosclerosis decline. Thus, contribute ESRD who benefit nephroprotective treatments.