Red blood cells from pluripotent stem cells for use in transfusion

摘要: The use of donated red blood cells in transfusion is a well-established cellular therapy. However, problems including insufficient supply, transfusion-transmitted infections and the need for immunological matching hamper even best services. These issues may be eliminated by using pluripotent stem to generate universal donor group O, Rhesus D-negative cells. Human embryonic can maintained expanded indefinitely can, therefore, produce very large cell numbers required this application. Red production also an attractive goal cell-derived therapeutics because it well-characterized single suspension, lacking nucleated with low expression HLA molecules. Much progress has been made; however, number challenges remain scale-up, clinical effectiveness product safety.