CT evaluation after neoadjuvant FOLFIRINOX chemotherapy for borderline and locally advanced pancreatic adenocarcinoma.

摘要: To assess anatomic changes on computed tomography (CT) after neoadjuvant FOLFIRINOX (5-fluorouracil/leucovorin/irinotecan/oxaliplatin) chemotherapy for secondary resected borderline resectable (BR) and locally advanced (LA) pancreatic adenocarcinoma their accuracy to predict resectability pathological response. Thirty-six patients with BR/LA (± chemoradiotherapy) were retrospectively included. Two radiologists reviewed baseline pre-surgical CTs in consensus. NCCN (National Comprehensive Cancer Network) classification, largest axis, product of the three axes (P3A), arterial/venous involvement studied compared response resection status disease-free survival (DFS). Thirty-one had R0 resection, including only six exhibiting a downstaging according classification. After treatment, axis P3A decreased (P   0.05). Progression vascular was seen two (5 %) led shorter DFS. In regimen chemoradiotherapy), significant tumour size decreases observed CT. However, CT staging not predictive • Significant chemoradiotherapy). is able accurately complete Even stable could have resection.