Histocompatibility antigens on melanoblasts and hair follicle cells. Cell-localized homograft rejection in allophenic skin grafts.

摘要: Histocompatibility antigens have been detected on melanoblasts and hair follicle cells by means of test grafting skin from allophenic mice containing two homozygous subpopulations with different alleles at the H-2 locus. Melanoblasts bore a visible color marker (e.g., B/B ↩ b/b) were marked agouti locus (A/A a/a). In grafts to parental isogenic strains, there was selective survival those whose phenotypes same strain as host, while foreign destroyed. Genotype-specific homograft rejection hosts highly localized homologous cells, even when genotypic cell strains admixed within single bulb. Donor had some individual hairs both black brown pigment granules attributable b/b respectively, or intermediate degrees banding presence A/A a/a cells; only one pure contributed such follicles after incompatible cells. The morphogenesis mosaic strikingly modified clonal components eliminated. Hair in situ also sometimes differed contained melanoblasts, e.g., C57BL/6 entered BALB/c produced pheomelanin. “Allogeneic inhibition” did not occur any these animals despite diverse antigenic types.