The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

摘要: Growth hormone factor 1 (GHF-1) is a pituitary-specific transcription that plays critical role in cell type-specific expression of the growth (GH) gene. Here, we describe isolation bovine and rat GHF-1 cDNA clones. These cDNAs encode proteins whose molecular mass, 33K, identical to purified sequence agrees with partial peptide sequence. The predicted contains region, near its C-terminus, exhibits considerable similarity homeobox consensus DNAase I footprinting bacterially expressed fusion protein containing fragment encompassing indicates this region functions as DNA binding domain. Expression restricted cells somatotropic lineage pituitary. This remarkable specificity correlates selective target, GH Other mammalian homeobox-containing may function similarly factors controlling other locations.