Stress affects dopaminergic signaling pathways in Drosophila melanogaster

摘要: Behaviors modulated by dopamine appear to be conserved across species. In the model system Drosophila melanogaster, as in mammals, modulates female sexual receptivity, a simple form of learning and responses drugs abuse. Synthesis, reuptake binding are also evolutionarily conserved. Since stress has been shown affect dopaminergic signaling pathways we investigated consequences exposure diverse stressors on physiology fruit fly, D. melanogaster. Animals were exposed metabolic (starvation), an oxidative (via superoxide anion generator paraquat) or mechanical (gentle vortexing). Sexual maturity, reproductive status, gender type differentially affected survival. The paradigms resulted alterations activity tyrosine hydroxylase, rate-limiting enzyme biosynthesis. Exposure these perturbed receptivity ovarian development, which dopamine, suggesting that is consequence stress. Transgenic with reduced levels neuronal displayed altered response stressors, that, key element response.