Chronic stress augments the long-term and acute effects of methamphetamine.

摘要: Abstract There is growing evidence that exposure to stress alters the acute effects of abused drugs on CNS. However, it not known whether augments longer-term neurotoxic psychostimulant drugs, such as methamphetamine. Methamphetamine at high doses decreases forebrain dopamine concentrations. The current study tested hypothesis 10 days unpredictable augmented striatal depletions 7 following four injections either 7.5 or 10 mg/kg methamphetamine (1 injection every 2 h). Furthermore, assess chronic immediate responses methamphetamine, extracellular and concentrations, rectal temperature were monitored during regimen. Seven a 7.5 mg/kg regimen, male rats exposed showed greater in tissue content compared with non-stressed controls injected Stressed had increased hyperthermic efflux striatum when control rats. Moreover, stressed an mortality rate (33%) (16.7%) enhanced was due concentrations striatum, levels regimen did differ between two groups. In summary, well methamphetamine-induced hyperthermia levels. These findings suggest increases responsiveness brain pharmacological enhances vulnerability psychostimulants.