CHAPTER 70 – Signaling by the Platelet-Derived Growth Factor Receptor Family
作者： M.V. Kovalenko , Andrius Kazlauskas
DOI: 10.1016/B978-012124546-7/50431-9
关键词:
摘要: The platelet-derived growth factor (PDGF) family causes cellular responses by engaging its cell-surface receptors. These receptors are tyrosine kinases, which initiate many signaling cascades that result in cell proliferation, motility, and survival. This chapter reviews current understanding of the enzymes serve as intracellular effectors PDGF In addition, it discusses impact integrins. Phosphotyrosine phosphatases (PTPs), cycle on PDGF-induced pathways subsequent responses. At present, four genes encoding different chains known: A, B, C, D. Biologically active PDGFs exist disulfide-bonded homodimers designated AA, BB, CC, DD.
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