Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
作者： Einar Martin Aandahl , Pål Aukrust , Bj⊘rn S. Skålhegg , Fredrik Müller , Stig S. Fr⊘land
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摘要: Cyclic AMP-dependent protein kinase A (PKA) type I has been established as an acute inhibitor of T cell activation. For this reason, we investigated the possible role PKA in HIV-induced dysfunction. cells from HIV-infected patients have increased levels cAMP and are more sensitive to inhibition by analog than normal cells. I-selective antagonist increases impaired proliferation or subnormal (up 2.8-fold). Follow-up after initiation highly active antiretroviral treatment revealed that a majority persistent dysfunction is normalized incubation with Rp-8-Br-cAMPS. These observations imply activation may contribute progressive HIV infection be potential target for immunomodulating therapy.—Aandahl, E. M., Aukrust, P., Skalhegg, B. S., Muller, F., Froland, S. H...
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