Conformational polymorphism of a zinc complex with enalapril antihypertensive drug
作者： Márcia C. de Souza , Chris H.J. Franco , Carlos B. Pinheiro , Renata Diniz
DOI: 10.1016/J.POLY.2014.06.025
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摘要: Abstract The crystal structure of an enalapril-Zn complex was determined by X-ray diffraction at various temperatures. consisted the drug enalapril coordinated to a Zn2+ ion oxygen atom carboxylate group in monodentate mode. metal produced tetrahedral geometry, indicating that complexation with vitro is similar suggested vivo. showed irreversible order–disorder structural phase transition temperature range 150–200 K during cooling process. A symmetry change from C222 room (Phase I) P212121 150 K II) observed. Phase I presented pronounced occupational disorder, whereas II slightly disordered.
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