Anticholinergic drugs versus placebo for overactive bladder syndrome in adults

摘要: Background Around 16% of adults have symptoms overactive bladder (urgency with frequency and/or urge incontinence). The prevalence increases age. Anticholinergic drugs are commonly used to treat this condition. Objectives To determine the effects anticholinergic for treatment syndrome. Search methods We searched Cochrane Incontinence Group Specialised Trials Register (searched 14 June 2005) and reference lists relevant articles. Selection criteria Randomised or quasi-randomised trials in syndrome that compared an drug placebo no treatment. Data collection analysis Two reviewer authors independently assessed eligibility, trial quality extracted data. Data were processed as described Handbook Systematic Reviews Interventions (Higgins 2005). Main results Sixty -one trials, 42 parallel-group designs 19 crossover included (11,956 adults). Most double-blind but variable other aspects quality. did not present data a way allowed inclusion meta-analysis. Nine medications tested: darifenacin; emepronium bromide carrageenate; oxybutynin; propiverine; propantheline; tolterodine; trospium chloride; solifenacin. One newer, slow release formulation tolterodine. At end period, cure improvement (relative risk (RR) 1.39, 95%CI 1.28 1.51), difference leakage episodes 24 hours (weighted mean (WMD) -0.54; 95% CI -0.67 -0.41) number voids (WMD -0.69; -0.84 -0.54) statistically significant favouring medication. Statistically modest sized improvements life scores reported recently completed trials. There was three times rate dry mouth medication group (RR 3.00 2.70 3.34) withdrawal 1.11, 0.91 1.36). Sensitivity analysis, while limited by small numbers showed little likelihood modified age, sex, diagnosis, choice drug. Authors' conclusions The use people results symptoms. Recent suggest is associated life. Dry common side effect therapy seem on withdrawals. It clear whether any benefits sustained during long-term after stops.