Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat

摘要: Abstract The behavioral and neurochemical effects of switching from typical to atypical medications have not been evaluated in the rodent models tardive dyskinesia. Thus, we treated rats with haloperidol–decanoate for 12 weeks, assessed additional treatment olanzapine, haloperidol, clozapine, or vehicle on vacuous chewing movements expression transcripts dopamine receptors, tyrosine hydroxylase, δ-opioid receptor, prodynorphin, preproenkephalin, glutamic acid decarboxylase-65 (glutamic decarboxylase (GAD)-65) GAD-67 N -methyl-D-aspartate (NMDA) receptor subunits striatum its efferent pathways. Haloperidol–decanoate induced extinguished following an 4 weeks vehicle, olanzapine but clozapine. Post-treatment, clozapine group were significantly higher than haloperidol groups. mRNA globus pallidus was decreased Changes other detected. These findings demonstrate important differences antipsychotics chronic movements.