Emerging gonadotropin-releasing hormone agonists

摘要: Introduction: Gonadotropin-releasing hormone agonist analogs (GnRHa) are peptides that mimic the action of gonadotropin-releasing (GnRH) and used to suppress subsequent sex steroid production. Although a rather defined group drugs, there have been developments in past decades is still ample room for improvement. New therapeutic strategies use GnRHs discussed. Areas covered: Major points discussion include: i) concomitant treatment early breast cancer premenopausal estrogen-positive -negative patients, ii) GnRHa fertility preservation young female patients with malignant diseases iii) GnRH assisted reproduction. The manuscript provides better understanding agonists as well an explanation their major indications, biochemical pathways concluding strategies. Recent results from international meetings debates described explain current controve...