Cannabidiol Isolated From Cannabis sativa L. Protects Intestinal Barrier From In Vitro Inflammation and Oxidative Stress

摘要: The relevance and incidence of intestinal bowel diseases (IBD) have been increasing over the last 50 years current therapies are characterized by severe side effects, making essential development new strategies that combine efficacy safety in management human IBD. Herbal products highly considered research aimed at discovering approaches for IBD therapy and, among others, Cannabis sativa L. has traditionally used centuries as an analgesic anti-inflammatory remedy also different gastrointestinal disorders. This study aims to investigate effects C. isolated compounds vitro model epithelium. ability treatments modulate markers dysfunctions was tested on Caco-2 cell monolayers. Our results, obtained evaluation ROS production, TEER paracellular permeability measurements tight junctions show Cannabidiol most promising compound against inflammatory condition. is able inhibit production restore epithelial during oxidative stress conditions, suggesting its possible application adjuvant management.