PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release
作者： Sun Young Lee , Dae Youn Hwang , Young Kyu Kim , Jae Woong Lee , Im Chul Shin
关键词:
摘要: SPECIFIC AIMSTo determine neurotoxic mechanisms of PS2 mutation, disruption cellular calcium homeostasis through ryanodine receptor pathway, interaction between and receptor, sensitization neurons to neurotoxicants by activation caspase-3 activity were investigated in the stably transfected PC12 cells cortical from transgenic mice expressing wild or mutant (N141I).PRINCIPAL FINDINGS1. Increased vulnerability, intracellular level, colocalization RyR neuronal PS2PC12 significantly more vulnerable against L-glutamate Aβ treatment compared with wild-type (WT) PS2, WT mice, as determined MTT reduction assay cells, Trypan blue staining neuron DAPI (data not shown). To whether mutations increase release the...
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