Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease
作者： Charlene Supnet , Ilya Bezprozvanny
关键词: Cognitive decline 、 Neuroscience 、 Excitotoxicity 、 Biology 、 Calpain 、 Calcium signaling 、 Pathogenesis 、 Endoplasmic reticulum 、 Mitochondrion 、 Biochemistry of Alzheimer's disease 、 Clinical psychology 、 Geriatrics and Gerontology 、 Psychiatry and Mental health 、 General Medicine
摘要: … Aβ 42 levels, disturbances in neuronal calcium (Ca 2+) … mitochondrial function in AD neurons. We conclude that inhibitors and stablizers of neuronal Ca 2+ signaling and mitochondrial …
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Fabrizio Trinchese, Mauro Fa’, Shumin Liu, Hong Zhang, Ariel Hidalgo, Stephen D. Schmidt, Hisako Yamaguchi, Narihiko Yoshii, Paul M. Mathews, Ralph A. Nixon, Ottavio Arancio, Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease Journal of Clinical Investigation. ,vol. 118, pp. 2796- 2807 ,(2008) , 10.1172/JCI34254
Maria Manczak, Thimmappa S. Anekonda, Edward Henson, Byung S. Park, Joseph Quinn, P. Hemachandra Reddy, Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression Human Molecular Genetics. ,vol. 15, pp. 1437- 1449 ,(2006) , 10.1093/HMG/DDL066
Jun Wu, Qin Li, Ilya Bezprozvanny, Evaluation of Dimebon in cellular model of Huntington's disease Molecular Neurodegeneration. ,vol. 3, pp. 15- 15 ,(2008) , 10.1186/1750-1326-3-15
Sun Young Lee, Dae Youn Hwang, Young Kyu Kim, Jae Woong Lee, Im Chul Shin, Ki Wan Oh, Myung Koo Lee, Jong Seok Lim, Do Young Yoon, Se Jin Hwang, Jin Tae Hong, PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release The FASEB Journal. ,vol. 20, pp. 151- 153 ,(2005) , 10.1096/FJ.05-4017FJE;1
Kim N. Green, Angelo Demuro, Yama Akbari, Brian D. Hitt, Ian F. Smith, Ian Parker, Frank M. LaFerla, SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production Journal of Cell Biology. ,vol. 181, pp. 1107- 1116 ,(2008) , 10.1083/JCB.200706171
Lars O. Tjernberg, Camilla Nilsberth, Sharon E. Pursglove, Akira Ito, Bengt Winblad, Richard F. Cowburn, Johan Thyberg, Maria Ankarcrona, Camilla A. Hansson, Susanne Frykman, Mark R. Farmery, Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria Journal of Biological Chemistry. ,vol. 279, pp. 51654- 51660 ,(2004) , 10.1074/JBC.M404500200
I. Okun, S. Tkachenko, A. Khvat, O. Mitkin, V. Kazey, A. Ivachtchenko, From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon. Current Alzheimer Research. ,vol. 7, pp. 97- 112 ,(2010) , 10.2174/156720510790691100
John W Steele, Soong H Kim, John R Cirrito, Deborah K Verges, Jessica L Restivo, David Westaway, Paul Fraser, Peter Hyslop, Mary Sano, Ilya Bezprozvanny, Michelle E Ehrlich, David M Holtzman, Sam Gandy, Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo Molecular Neurodegeneration. ,vol. 4, pp. 51- 51 ,(2009) , 10.1186/1750-1326-4-51
Grace E Stutzmann, Antonella Caccamo, Frank M LaFerla, Ian Parker, Dysregulated IP3 Signaling in Cortical Neurons of Knock-In Mice Expressing an Alzheimer's-Linked Mutation in Presenilin1 Results in Exaggerated Ca2+ Signals and Altered Membrane Excitability The Journal of Neuroscience. ,vol. 24, pp. 508- 513 ,(2004) , 10.1523/JNEUROSCI.4386-03.2004
Malcolm A Leissring, Yama Akbari, Christopher M Fanger, Michael D Cahalan, Mark P Mattson, Frank M LaFerla, None, Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice Journal of Cell Biology. ,vol. 149, pp. 793- 798 ,(2000) , 10.1083/JCB.149.4.793