Calcium‐overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa

作者: Miyuki Kinebuchi , Akihiro Matsuura

DOI: 10.1002/AMS2.100

关键词:

摘要: Aim We aimed to show the status of intracellular elements in sympathetic preganglionic neurons an autopsy case a 55-year-old woman with severe sepsis and cardiac dysfunction anorexia nervosa. Methods Our methods include report pathological examinations autopsied tissues using synchrotron-generated microbeam X-ray fluorescence analysis. Results A myocardial dysfunction. The patient had sudden short arrest without arrhythmia sequelae, echocardiogram showed negative inotropic change. analysis indicated unusually high concentration cytosolic calcium neurons. However, there were no significant findings damage heart or cardiovascular autonomic nuclei central nervous system. Conclusion The data indicate that exists nervosa.

参考文章(23)
Juming Zhong, Tzyh-Chang Hwang, H. Richard Adams, Leona J. Rubin, Reduced L-type calcium current in ventricular myocytes from endotoxemic guinea pigs American Journal of Physiology-heart and Circulatory Physiology. ,vol. 273, ,(1997) , 10.1152/AJPHEART.1997.273.5.H2312
Charlene Supnet, Ilya Bezprozvanny, Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease Journal of Alzheimer's Disease. ,vol. 20, pp. S487- S498 ,(2010) , 10.3233/JAD-2010-100306
Tarek Sharshar, Djillali Annane, Geoffroy Lorin de la Gradmaison, Jean Philippe Brouland, Nicholas S Hopkinson, Françoise Gray, The neuropathology of septic shock Brain Pathology. ,vol. 14, pp. 21- 33 ,(2004) , 10.1111/J.1750-3639.2004.TB00494.X
Tomoya Irie, Lin Zou, Shohei Shinozaki, Michihiro Sakai, Nobuyuki Shimizu, Rebecca Nguyen, Jonathan S. Stamler, Wei Chao, Masao Kaneki, Fumito Ichinose, Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression American Journal of Physiology-heart and Circulatory Physiology. ,vol. 304, ,(2013) , 10.1152/AJPHEART.00887.2012
Hsueh-Meei Huang, Huan-Lian Chen, Gary E. Gibson, Thiamine and Oxidants Interact to Modify Cellular Calcium Stores Neurochemical Research. ,vol. 35, pp. 2107- 2116 ,(2010) , 10.1007/S11064-010-0242-Z
Yan Feng, Lin Zou, Ming Zhang, Yan Li, Chan Chen, Wei Chao, MyD88 and Trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis. Anesthesiology. ,vol. 115, pp. 555- 567 ,(2011) , 10.1097/ALN.0B013E31822A22F7
Kevin J. Tracey, The inflammatory reflex Nature. ,vol. 420, pp. 853- 859 ,(2002) , 10.1038/NATURE01321
Ion A Hobai, Emmanuel S Buys, Justin C Morse, Jessica Edgecomb, Eric H Weiss, Antonis A Armoundas, Xiuyun Hou, Alok R Khandelwal, Deborah A Siwik, Peter Brouckaert, Richard A Cohen, Wilson S Colucci, None, SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 305, ,(2013) , 10.1152/AJPHEART.00392.2012
Chang-seng Liang, Naomi Kenmotsu Rounds, Erdan Dong, Suzanne Y. Stevens, Junya Shite, Fuzhong Qin, Alterations by norepinephrine of cardiac sympathetic nerve terminal function and myocardial β-adrenergic receptor sensitivity in the ferret: Normalization by antioxidant vitamins Circulation. ,vol. 102, pp. 96- 103 ,(2000) , 10.1161/01.CIR.102.1.96
Vedrana Tadic, Tino Prell, Janin Lautenschlaeger, Julian Grosskreutz, The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis Frontiers in Cellular Neuroscience. ,vol. 8, pp. 147- 147 ,(2014) , 10.3389/FNCEL.2014.00147