cRGD Conjugated mPEG-PLGA-PLL Nanoparticles for SGC-7901 Gastric Cancer Cells-Targeted Delivery of Fluorouracil

摘要: The main purpose of this study was to evaluate the targeting effect cyclic arginine-glycine-aspartic peptide (cRGD)-modified monomethoxy (polyethylene glycol)-poly (D, L-lactide-co-glycolide)-poly (L-lysine) nanoparticles (mPEG-PLGA-PLL-cRGD NPs) for gastric cancer SGC-7901 cells. We prepared 5-Fulorouracil (5Fu)-loaded mPEG-PLGA-PLL-cRGD (5Fu/mPEG-PLGA-PLL-cRGD) NPs that had an average particle size 180 nm and a zeta potential 2.77 mV. results cytotoxicity demonstrated showed ignorable 5Fu/mPEG-PLGA-PLL-cRGD could significantly enhance 5Fu. In vitro drug release experiments effectively prolonged sustained. confocal laser scanning microscope (CLSM) flow cytometer analysis fluorescence intensity cells treated with Rb/mPEG-PLGA-PLL-cRGD higher than Rb, suggested be internalized by summary, above experimental illustrate have great used as effective delivery carriers.