Developing models for cachexia and their implications in drug discovery

摘要: Introduction: Cachexia is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle or without fat mass. Systemic inflammation plays central role in its pathophysiology. As millions patients are cachectic state chronic disease, cachexia one the major causes death worldwide. Difficulties recruitment follow-up clinical trials mean that well-characterized animal models great importance developing therapies. However, some widely used have limitations procedural reproducibility recapitulating phenotype, which has warranted development novel for cachexia.Areas covered: This review focuses on currently rodent designed to mimic each co-morbidity cachexia.Expert opinion: Through cancer models, researchers been seeking more targets intervention. In cardiac cachexia, technical issues ov...