Aspirin and Dipyridamole Decrease Intimal Hyperplasia in Experimental Vein Grafts

摘要: Release from platelets of a factor mitogenic for smooth muscle cells is postulated mechanism the pathogenesis vascular intimal hyperplasia. In this study effect antiplatelet therapy was evaluated. Aspirin (165 mg twice daily) and dipyridamole (25 were administered to six rhesus monkeys given placebo only. Bilateral vein bypass grafts placed in iliac arteries. addition, evaluate relative contribution adventitial dissection injury, on one side carotid artery femoral stripped adventitia other intima these vessels injured by single passage an inflated balloon tipped catheter. Animals killed after 16 weeks. luminal area determined photographic gravimetric method at three standard locations. Femoral veins arteries classified as histologically normal or exhibiting All with stripping normal. injury group except exhibited hyperplasia compared drug treated which over half Relative significantly less animals all locations greater two. These data suggest that can be reduced treatment agents.