Eicosapentanoic acid suppresses intimal hyperplasia after expanded polytetrafluoroethylene grafting in rabbits fed a high cholesterol diet.
作者： Masaki O-hara , Kensuke Esato , Mikihiko Harada , Yasuhiro Kouchi , Fumikazu Akimoto
DOI: 10.1016/0741-5214(91)90301-A
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摘要: Abstract The effect of purified eicosapentanoic acid on intimal fibrous hyperplasia in expanded polytetrafluoroethylene grafts was examined 18 rabbits undergoing infrarenal aorta reconstruction. Six received commercial rabbit chow (control group), six a regular diet supplemented with 1% cholesterol (cholesterol and the 91.1% pure 500 mg/day (eicosapentanoic group). Grafts were harvested 3 months after surgery for histologic examination. platelet count serum β-thromboglobulin factor 4 concentrations not significantly different between groups. Serum arachidonic level group higher than control group, levels remaining two Intergroup differences 6-keto-prostaglandin F 1α thromboxane B 2 significant. Intimal thickness at midgraft 5.2 ± 6.2 μm 67.6 46.9 19.2 18.4 group. greater either or licosapentanoic ( p ratio. (J VASC SURG 1991;13:480-6.)
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sci-hub.se 参考文章(30)
Clowes Aw, Reidy Ma, Gown Am, Hanson, Mechanisms of arterial graft failure. 1. Role of cellular proliferation in early healing of PTFE prostheses. American Journal of Pathology. ,vol. 118, pp. 43- 54 ,(1985)
Clowes Aw, Reidy Ma, Clowes Mm, Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Laboratory Investigation. ,vol. 49, pp. 327- ,(1983)
R.G. Hendrickse, A. Adeniyi, G.M. Edington, E.F. Glasgow, R.H.R. White, V. Houba, QUARTAN MALARIAL NEPHROTIC SYNDROME The Lancet. ,vol. 299, pp. 1143- 1149 ,(1972) , 10.1016/S0140-6736(72)91373-6
R. L MCCANN, P-O. HAGEN, J. C. A. FUCHS, Aspirin and Dipyridamole Decrease Intimal Hyperplasia in Experimental Vein Grafts Annals of Surgery. ,vol. 191, pp. 238- 243 ,(1980) , 10.1097/00000658-198002000-00018
YASUSHI TAMURA, AIZAN HIRAI, TAKASHI TERANO, SHO YOSHIDA, MITSUKO TAKENAGA, HARUO KITAGAWA, Anti-thrombotic and anti-atherogenic action of eicosapentaenoic acid. Japanese Circulation Journal-english Edition. ,vol. 51, pp. 471- 477 ,(1987) , 10.1253/JCJ.51.471
Russell Ross, Arthur Vogel, The platelet-derived growth factor Cell. ,vol. 14, pp. 203- 210 ,(1978) , 10.1016/0092-8674(78)90107-1
J DYERBERG, EICOSAPENTAENOIC ACID AND PREVENTION OF THROMBOSIS AND ATHEROSCLEROSIS The Lancet. ,vol. 312, pp. 117- 119 ,(1978) , 10.1016/S0140-6736(78)91505-2
J. Nilsson, M. Sjolund, L. Palmberg, J. Thyberg, C. H. Heldin, Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 4418- 4422 ,(1985) , 10.1073/PNAS.82.13.4418
Zeljko S. Radic, Michael K. O'Malley, Eileen M. Mikat, Raymond G. Makhoul, Richard L. McCann, C. William Cole, Per-Otto Hagen, The role of aspirin and dipyridamole on vascular DNA synthesis and intimal hyperplasia following deendothelialization. Journal of Surgical Research. ,vol. 41, pp. 84- 91 ,(1986) , 10.1016/0022-4804(86)90013-2
P. E. DiCorleto, D. F. Bowen-Pope, Cultured endothelial cells produce a platelet-derived growth factor-like protein Proceedings of the National Academy of Sciences of the United States of America. ,vol. 80, pp. 1919- 1923 ,(1983) , 10.1073/PNAS.80.7.1919