The role of aspirin and dipyridamole on vascular DNA synthesis and intimal hyperplasia following deendothelialization.

摘要: Abstract Platelets are implicated both in acute thrombotic events and, through platelet-derived growth factor, the development of intimal hyperplasia. We have investigated, vivo , influence aspirin and dipyridamole on vascular smooth muscle cell proliferation DNA synthesis following balloon catheter injury. Fifty-eight male, New Zealand white rabbits were divided equally into two groups; test group was fed (14 mg/kg/day) (9 from 2 days prior to surgery until sacrifice at 1, 2, 3, 4, 7, 14, or 28 after All animals sacrificed 1 h injection [ 3 H]thymidine specific activity total kinetic determined. Intimal hyperplasia measured by light microscopy nuclear determined counting nuclei per millimeter internal elastic lamina. Nuclear maximal 14 (25 ± 1.2) but still increasing days. 24 hr (test: 4 dpm/μg DNA; control: 3.3 DNA) similar basal levels uninjured rabbits. peaked groups between second third day 177 27 185 39 then declined slowly toward baseline values. There no significant difference treated normal either incorporation, proliferation, despite 90% inhibition platelet aggregation a reduction (78%) C]serotonin release collagen challenge (6 μg/ml). These results suggest presence another factor(s) for rabbit as global interference with platelets does not inhibit proliferation.