The utility of animal models in the preclinical study of interventions to prevent human coronary artery restenosis : Analysis and recommendations: On behalf of the subcommittee on animal, cellular and molecular models of thrombosis and haemostasis of the scientific and standardization committee of the international society on thrombosis and haemostasis

摘要: Small animal models have several advantageous characteristics, but those used in preclinical restenosis research lacked efficacy predicting the success of interventions to inhibit humans. Large been more successful than small humans, results studies carried out with these not uniformly predictive. Confirmation large animals has always yielded information predictive humans; however, absence such confirmation had strong negative value. for evaluation luminal narrowing following arterial instrumentation failed closely simulate human atherosclerosis and stenotic lesions subjected Transgenic, atherosclerotic hold promise development useful study mechanisms response diseased arteries angioplasty stents. The pig most stenosis/ restenosis, is needed overcome limitations this model.