Endovascular β-Radiation to Reduce Restenosis After Coronary Balloon Angioplasty Results of the Beta Energy Restenosis Trial (BERT)

摘要: Background—In the porcine overstretch injury model of restenosis, endovascular β-radiation reduces neointima formation. To determine whether this therapy could be applied to patients with coronary artery disease, a special device was developed allow delivery 12 encapsulated 90Sr/Y sources, measuring total 30 mm, various sites within arterial tree. This study designed evaluate feasibility 12, 14, or 16 Gy at 2 mm after balloon angioplasty stenoses native vessels. Methods and Results—Delivery attempted in 23 successful angioplasty. Source 21 (91%). There no in-hospital 30-day morbidity mortality. Follow-up quantitative arteriography 20 demonstrated late loss 0.05 index 4%, restenosis rate 15%. The use β-emitter significantly reduced treatment time operator exposure comp...