REVERSIBILITY OF THE EFFECTS OF ACTIVE IMMUNIZATION AGAINST LH-RH

摘要: This chapter discusses reversibility of the effects active immunization against luteinizing hormone–releasing hormone (LH–RH). Active LH–RH might be considered as an alternative to surgical intervention in treatment cryptorchism. In horses, this condition often requires extensive abdominal surgery that not only involves a risk infection, but is also costly. on other hand induce regression retained testis or testes, thereby inhibiting further testosterone secretion and preventing undesirable behavior. The methods reversal effects. It highlights inhibitory high antibody titers overcome by administration large amounts LH–RH, with immunologically distinct analogue LH–RH. Treatment saturate binding capacity circulating antibodies, allowing excess again stimulate anterior pituitary gland. An would recognized antibodies might, therefore, effective face continued titers. Reversal occur following natural decline titer absence boosting immunizations.