Pharmacogenetics of the response to antihypertensive drugs

摘要: In the United States, only about one third of hypertensive individuals successfully control their blood pressure. One reason for this is unpredictable response have to treatment. Clinicians often rely on empirical methods match patients with effective Hypertension pharmacogenetics seeks find genetic predictors drugs that reduce pressure or unfavorable cardiovascular outcomes. For more than a decade, investigators been assessing associations between polymorphisms and antihypertensive drugs. This article reviews 29 studies published since 2008. Although inconsistent findings remain common, trends are emerging several gene-treatment combinations. Nevertheless, researchers continue cite differences in study design, variable pharmacologic exposures, small sample sizes as explanations these inconsistencies. Assuming common variation plays role drugs, disciplinary progress hinges our ability launch large using high-fidelity phenotyping multiple ethnic groups.