Study on the mechanism of cantharidin‐induced hepatotoxicity in rat using serum and liver metabolomics combined with conventional pathology methods
作者： Jianyong Zhang , Qihong Chen , Le Wang , Kuan Chen , Wenbi Mu
DOI: 10.1002/JAT.3983
关键词:
摘要: Cantharidin (CTD), a compound secreted from Mylabris species, exhibits strong antitumor properties; however, hepatotoxicity restricts its clinical application. The mechanism by which CTD induces toxicity remains unclear. In the present study, of in rat was investigated using metabolomic approach combined with conventional pathology methods. A total 30 rats were intragastrically treated two doses (0.75 and 1.5 mg/kg) for 15 days to evaluate hepatotoxicity. Serum liver samples collected biochemical dynamics analyses, histopathological examination analysis. It found that index serum indices significantly increased. Furthermore, results showed hepatocytes subcellular organelles damaged. Metabolomics analysis 4 biomarkers associated CTD-induced addition, these responsible glycerophospholipid metabolism, sphingolipid steroid hormone biosynthesis. conclusion, metabolomics exploring can provide useful information about safety potential risks CTD.
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