NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats.
作者： Xiaoyu Zhang , Huifeng Wu , Peiqiu Liao , Xiaojing Li , Jiazuan Ni
DOI: 10.1016/J.FCT.2005.12.004
关键词:
摘要: The subacute toxicity of aristolochic acid (AA) was investigated by (1)H NMR spectroscopic and pattern recognition (PR)-based metabonomic methods. Model toxins were used to enable comparisons the urinary profiles from rats treated with known toxicants AA at various time intervals. Urinary spectra data-processed analyzed method. result visual comparison showed that caused a renal proximal tubular papillary lesion slight hepatic impair. Pattern analysis indicated tubule main damage induced AA, progressive course accumulation dosage monitoring toxicological processes onset, development part-recovery. These results also supported conventional clinical biochemical parameters.
elsevier.com
core.ac.uk 
sci-hub.se 参考文章(37)
John C. Lindon, Jeremy K. Nicholson, Jeremy R. Everett, NMR Spectroscopy of Biofluids Annual reports on NMR spectroscopy. ,vol. 38, pp. 1- 88 ,(1999) , 10.1016/S0066-4103(08)60035-6
Frédéric Debelle, Joëlle Nortier, Volker M. Arlt, Eric De Prez, Anne Vienne, Isabelle Salmon, David H. Phillips, Monique Deschodt-Lanckman, Jean-Louis Vanherweghem, Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy Archives of Toxicology. ,vol. 77, pp. 218- 226 ,(2003) , 10.1007/S00204-003-0438-Y
John A Timbrell, None, Biomarkers in toxicology Toxicology. ,vol. 129, pp. 1- 12 ,(1998) , 10.1016/S0300-483X(98)00058-4
Hector C. Keun, Timothy M. D. Ebbels, Henrik Antti, Mary E. Bollard, Olaf Beckonert, Götz Schlotterbeck, Hans Senn, Urs Niederhauser, Elaine Holmes, John C. Lindon, Jeremy K. Nicholson, Analytical Reproducibility in 1H NMR-Based Metabonomic Urinalysis Chemical Research in Toxicology. ,vol. 15, pp. 1380- 1386 ,(2002) , 10.1021/TX0255774
J. K. Nicholson, J. C. Lindon, E. Holmes, 'METABONOMICS': UNDERSTANDING THE METABOLIC RESPONSES OF LIVING SYSTEMS TO PATHOPHYSIOLOGICAL STIMULI VIA MULTIVARIATE STATISTICAL ANALYSIS OF BIOLOGICAL NMR SPECTROSCOPIC DATA Xenobiotica. ,vol. 29, pp. 1181- 1189 ,(1999) , 10.1080/004982599238047
Nigel J. Waters, Elaine Holmes, Ann Williams, Catherine J. Waterfield, R. Duncan Farrant, Jeremy K. Nicholson, NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach. Chemical Research in Toxicology. ,vol. 14, pp. 1401- 1412 ,(2001) , 10.1021/TX010067F
V. M. Arlt, Sequence-specific detection of aristolochic acid-DNA adducts in the human p53 gene by terminal transferase-dependent PCR Carcinogenesis. ,vol. 22, pp. 133- 140 ,(2001) , 10.1093/CARCIN/22.1.133
H. Zhang, M.A. Cifone, H. Murli, G.L. Erexson, M.S. Mecchi, T.E. Lawlor, Application of simplified in vitro screening tests to detect genotoxicity of aristolochic acid. Food and Chemical Toxicology. ,vol. 42, pp. 2021- 2028 ,(2004) , 10.1016/J.FCT.2004.07.016
Andrew W. Nicholls, Elaine Holmes, John C. Lindon, John P. Shockcor, R. Duncan Farrant, John N. Haselden, Stephen J. P. Damment, Catherine J. Waterfield, Jeremy K. Nicholson, Metabonomic Investigations into Hydrazine Toxicity in the Rat Chemical Research in Toxicology. ,vol. 14, pp. 975- 987 ,(2001) , 10.1021/TX000231J
U. Mengs, On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid Archives of Toxicology. ,vol. 52, pp. 209- 220 ,(1983) , 10.1007/BF00333900