Cancer following breast reduction surgery in Denmark

摘要: Intuitively, breast tissue mass should be directly related to a woman'srisk of cancer, simply because having more cells at risk would seem toincrease the potential for malignant transformation. However, studiesattempting link size with cancer have beeninconsistent. Limitations include crude measures size, theinability distinguish glandular from adipose tissue, and confoundinginfluence co-factors such as obesity. A nationwide study in Denmark wasundertaken investigate effect reduction surgery on thesubsequent including an evaluation patterns ofrisk by age time since surgery. The Danish Hospital Discharge Registrywas used identify women who underwent mammaplasty between 1977and 1992. Linkage based personal identification numbers DanishCancer Registry provided information incidence. Expected ofcancers were calculated rates general population. Among 7,720women whose breasts surgically reduced, 182 cancers subsequentlyobserved cf 209 expected (standardized incidence ratio [SIR] = 0.9; 95percent confidence interval [CI] 0.7-1.0). Breast was significantlyreduced nearly 50 percent (29 observed 53.9 expected, SIR 0.5, CI =0.4-0.8), accounted overall deficit cancer. riskreductions inversely surgery, significantdeficits apparent only among 40 years older andespecially those over (SIR 0.3). No clear trend apparentwith increasing post-surgery. findings indicate that breastreduction is associated lowersubsequent but presumably glandularmass appear less closely youngerwomen.