Restriction of HIV Replication in Infected T Cells and Monocytes by Interferon-α

摘要: Human recombinant interferon-alpha (IFN alpha) restricted viral replication in human immunodeficiency virus- (HIV) infected T cells and monocytes. With cells, reverse transcriptase (RT) activity culture fluids was reduced threefold from that of control by IFN treatment, but HIV p24 antigen levels were unchanged. In contrast, RT lysates IFN-treated greater than those controls. These differences suggest the mechanism for IFN-induced antiviral effects HIV-infected resides terminal events (assembly release) virus cycle. Monocytes treated with at time challenge showed no or activity, HIV-specific mRNA, proviral DNA up to 3 weeks after infection. treatment chronically monocytes also decreased replication, as assessed antigen, mRNA detection assays. However, indistinguishable. The presence large quantities little evidence active transcription documents a situation approaching true microbiological latency.