Structural and functional roles of 2'-O-ribose methylations and their enzymatic machinery across multiple classes of RNAs.
作者： Simone Höfler , Teresa Carlomagno
DOI: 10.1016/J.SBI.2020.05.008
关键词:
摘要: RNA complexity is augmented by numerous post-transcriptional modifications, which influence function modulating its structure and interactome. One prominent modification methylation at the ribose 2'-hydroxyl group. 2'-O-methylation has been found in all classes, with rRNA tRNA being extensively modified. The exact of specific sites still not understood, a few notable exceptions. relevance for cell survival well-being proven large effort that spends maintaining diverse highly regulated machinery. Here, we review current knowledge on impact different RNAs as well factors determining substrate specificity enzymatic
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