Combing the genome for genomic instability

摘要: Genomic instability is one of the major features cancer cells. The clinical phenotypes associated with several human diseases have been linked to recurrent DNA rearrangements and dysfunction replication processes that involve unstable genomic regions. Analysis these rearrangements, which are frequently submicroscopic can lead loss or gain dosage-sensitive genes gene disruption, requires development sensitive, high-resolution techniques. This will a better understanding mechanisms underlying genome greater awareness role chromosomal in disease. A new technology involves molecular combing, method permits straightening aligning molecules DNA, should make possible detailed analysis events at level single molecules. Such molecule approach could help elucidate important properties masked bulk studies.