Results of randomized controlled trials of low-versus high-osmolality contrast media.

摘要: The authors reviewed 100 randomized controlled trials (RCTs) conducted in humans to compare safety or efficacy of new low-osmolality contrast media (LOM) with that high-osmolality (HOM). Findings the 43 RCTs judged be highest quality suggest LOM imaging is equal superior HOM for all routes administration. Heat sensation occurred less often and pain intraarterial routes. No differences were seen nephrotoxicity frequency nausea, vomiting, urticaria, bronchospasm, laboratory test abnormalities, neurologic events. Greater cardiovascular changes HOM, including increased decreased heart rate, left ventricular end-diastolic pressure, systolic QT prolongation, depending on route To demonstrate whether a reduction clinically significant adverse outcomes truly occurs LOM, will need enli...