Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells

摘要: Colorectal cancer (CRC) is one of the most deadly cancers worldwide. Significant progress has been made in understanding molecular pathogenesis CRC, which led to successful early diagnosis, surgical intervention and combination chemotherapy. However, limited therapeutic options are available for metastatic and/or drug-resistant CRC. While aberrantly activated Wnt/β-catenin pathway plays a critical initiating role CRC development, disruption bone morphogenetic protein (BMP) causes juvenile polyposis syndrome, suggesting that BMP signaling may play development. conflicting results have reported concerning possible roles sporadic colon cancer. Here, we investigated effect BMP2 on proliferation, migration, invasiveness tumor growth capability human cells. Using an adenovirus vector overexpresses piggyBac transposon-mediated stable overexpression line, found exogenous effectively inhibited HCT116 cell proliferation colony formation. was shown suppress migration invasiveness. Under low serum culture condition, forced expression induced significantly increased level apoptosis xenograft model, cells suppressed growth, accompanied by decreased activity. Taken together, our strongly suggest important inhibitory governing aggressive features