Wood combustion particles induce adverse effects to normal and diseased airway epithelia

作者: Manuel Krapf , Lisa Künzi , Sandrine Allenbach , Emily A Bruns , Ilaria Gavarini

DOI: 10.1039/C6EM00586A

关键词:

摘要: Residential wood burning is a major source of poorly characterized, deleterious particulate matter, whose composition and toxicity may vary with type, condition photochemical age. The causative link between ambient particle constituents observed adverse health effects currently lacking. Here we investigate the relationship chemical properties primary atmospherically aged combustion particles acute in human airway epithelial cells. Emissions from log burner were diluted injected into smog chamber for aging. After concentration-enrichment removal oxidizing gases, directly emitted deposited on cell cultures at air-liquid interface 2 hours an aerosol deposition mimicking physiological conditions lungs. Cell models fully differentiated normal diseased (cystic fibrosis asthma) bronchial epithelia (HBE) line BEAS-2B. responses assessed 24 after exposure. Atmospherically relevant doses significantly increased death all but asthma model. Expression oxidative stress markers HBE donors. Increased inflammatory could not be assigned to single fraction particles. Exposure caused epithelia, apparently induced by several interacting components.

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