Bioactive styryllactones and alkaloid from flowers of Goniothalamus laoticus.

摘要: Abstract Ethnopharmacological relevance Goniothalamus laoticus (Annonaceae) is being used traditionally as a tonic and febrifuge by the local people in northeastern part of Thailand. Aim study To investigate Thai medicinal plant, laoticus, for antiplasmodial, antimycobacterial cytotoxicity activities. Materials methods The flowers extracts were isolated chromatographic techniques. Structures compounds identified spectroscopic methods. evaluation styryllactone derivatives alkaloid also performed. Results Ten compounds, cinnamic acid (1); dihydrochrysine (2); β-sitosterol (3); six styryllactones, (+)-3-acetylaltholactone (4), goniotriol (5), (+)-altholactone (6), (+)-goniofufurone (7), 9-deoxygoniopypyrone (8), howiinin A (9); an aporphine alkaloid; (−)-nordicentrine (10) from laoticus. Among these, 1, 3–5, 8–10 are first Besides, compound 10 report genus. evaluated anticancer cell lines tests. Compounds 4–6 exhibited antiplasmodial activity against Plasmodium falciparum (IC50 2.6, 7.9, 2.6 0.3 μg/mL, respectively), while 5, 6, 9 showed Mycobacterium tuberculosis (MIC 100, 6.25, 6.25 12.5 μg/mL, respectively). In addition, 4–10 cancer cells, KB, BC1, NCI-H187, MCF-7 with IC50 ranging 0.4 to 22.7 μg/mL. Conclusion This finding that falciparum, antimycobacterail four lines.