Nicorandil: A Potassium Channel Opening Drug for Treatment of Ischemic Heart Disease

摘要: Nicorandil is the first oral potassium channel activating drug to be used for treatment of symptomatic coronary artery disease. It appears relax vascular smooth muscle through membrane hyperpolarization via increased transmembrane conductance and, like nitrates, an increase in intracellular cyclic GMP. In addition, nicorandil, a nitrate-like manner, dilates normal and stenotic arteries reduces both ventricular preload afterload. contrast however, nicorandil does not appear cause tolerance with long-term administration. placebo comparison clinical trials, has demonstrated some efficacy safety patients stable vasospastic angina pectoris, it was found myocardial protective agent animal studies. The antianginal activity relatively short lived after dosing, which will necessitate development extended-release formulations drug.