Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients
作者： Gustavo Pimentel Dutra , Gustavo L. Ottoni , Diogo R. Lara , Maurício Reis Bogo
DOI: 10.1590/S1516-44462010005000003
关键词:
摘要: OBJETIVO: A adenosina pode ter um papel importante na fisiopatologia da esquizofrenia, uma vez que modula a liberacao de varios neurotransmissores, tais como glutamato, dopamina, serotonina e acetilcolina, diminui atividade neuronal por hiperpolarizacao pos-sinaptica inibe dopaminergica. desaminase participa do metabolismo das purinas pela conversao em inosina. O mais frequente polimorfismo funcional (22G →A) (ADA1*2) exibe diminuicao 20-30% individuos com genotipo G/A quando comparados o G/G. objetivo deste estudo foi avaliar 22G→A pacientes esquizofrenicos controles saudaveis. METODO: Os genotipos ADA 22G →A foram identificados atraves estrategia PCR alelo-especifica 152 111 RESULTADOS: Foi observada significativa frequencia (7 - 4,6%) relacao ao grupo controle (13 11,7%, p = 0,032, OR 2,6). CONCLUSAO: Estes resultados sugerem associado baixa desaminase, potencialmente niveis aumentados adenosina, menos entre esquizofrenicos.
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