Hormonal regulation of pancreatic islet adenyl cyclase
作者： W. J. Thompson , D. G. Johnson , R. H. Williams
DOI: 10.1021/BI00653A011
关键词:
摘要: Adenyl cyclase activity of rat pancreatic islet membrane was increased by secretin, pancreozymin, and isoproterenol, while ACTH, glucagon, growth hormone, insulin had no effect. Both secretin isoproterenol activations were enhanced prostaglandin E1 (PGE1) GTP. Isoproterenol activation additive with PGE1, as that but only in the presence Secretin PGE1 GTP equivalent to NaF stimulation. Kinetic analysis indicated maximum velocity adenyl tended decrease apparent affinity enzyme for ATP. Glucagon dependent upon prior treatment preparation EGTA use inhibitors proteolytic enzymes during collagenase digestion phase preparation. These results suggest hormonal regulation secretion may be affected guanine nucleotide modulation process.
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Wu-Nan Kuo, Daniel S. Hodgins, J.F. Kuo, Adenylate cyclase in islets of Langerhans. Isolation of islets and regulation of adenylate cyclase activity by various hormones and agents. Journal of Biological Chemistry. ,vol. 248, pp. 2705- 2711 ,(1973) , 10.1016/S0021-9258(19)44063-5
Gopal Krishna, James P. Harwood, Alfred J. Barber, Graham A. Jamieson, Requirement for Guanosine Triphosphate in the Prostaglandin Activation of Adenylate Cyclase of Platelet Membranes Journal of Biological Chemistry. ,vol. 247, pp. 2253- 2254 ,(1972) , 10.1016/S0021-9258(19)45524-5
K. Dieter Hepp, Roswitha Edel, Otto Wieland, Hormone Action on Liver Adenyl Cyclase Activity FEBS Journal. ,vol. 17, pp. 171- 177 ,(1970) , 10.1111/J.1432-1033.1970.TB01150.X
Martin Rodbell, Michael C. Lin, Yoram Salomon, Evidence for interdependent action of glucagon and nucleotides on the hepatic adenylate cyclase system. Journal of Biological Chemistry. ,vol. 249, pp. 59- 65 ,(1974) , 10.1016/S0021-9258(19)43090-1
Martin Rodbell, Lutz Birnbaumer, Stephen L. Pohl, Adenyl Cyclase in Fat Cells III. STIMULATION BY SECRETIN AND THE EFFECTS OF TRYPSIN ON THE RECEPTORS FOR LIPOLYTIC HORMONES Journal of Biological Chemistry. ,vol. 245, pp. 718- 722 ,(1969) , 10.1016/S0021-9258(18)63322-8
Hans-Jürgen Hahn, Bo Hellman, Åke Lernmark, Janove Sehlin, Inge-Bert Täljedal, The Pancreatic β-Cell Recognition of Insulin Secretagogues: INFLUENCE OF NEURAMINIDASE TREATMENT ON THE RELEASE OF INSULIN AND THE ISLET CONTENT OF INSULIN, SIALIC ACID, AND CYCLIC ADENOSINE 3′:5′-MONOPHOSPHATE Journal of Biological Chemistry. ,vol. 249, pp. 5275- 5284 ,(1974) , 10.1016/S0021-9258(19)42360-0
Ira D. Goldfine, Jesse Roth, Lutz Birnbaumer, Glucagon Receptors in β-Cells BINDING OF 125I-GLUCAGON AND ACTIVATION OF ADENYLATE CYCLASE Journal of Biological Chemistry. ,vol. 247, pp. 1211- 1218 ,(1972) , 10.1016/S0021-9258(19)45636-6
W. Montague, J. R. Cook, The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans. Biochemical Journal. ,vol. 122, pp. 115- 120 ,(1971) , 10.1042/BJ1220115
W.J. Thompson, R.H. Williams, S.A. Little, Activation of guanyl cyclase and adenyl cyclase by secretin Biochimica et Biophysica Acta (BBA) - Enzymology. ,vol. 302, pp. 329- 337 ,(1973) , 10.1016/0005-2744(73)90161-7
John R. Turtle, David M. Kipnis, An adrenergic receptor mechanism for the control of cyclic 3′5′ adenosine monophosphate synthesis in tissues☆ Biochemical and Biophysical Research Communications. ,vol. 28, pp. 797- 802 ,(1967) , 10.1016/0006-291X(67)90388-9