Thrombin and epidermal growth factor become linked to cell surface receptors during mitogenic stimulation.

摘要: THERE is much evidence that interaction with specific cell surface receptors a key event in the action of polypeptide hormones and growth factors. Many analyses hormone–receptor interactions have been carried out based on assumption hormone binding to reversible reaction1–3. Indeed, many studies demonstrated bound dissociate from their receptors. However, most systems possibility could not be excluded significant fraction molecules bind cells become linked Our present mitogens 125I-thrombin 125I-epidermal factor (125I-EGF) show percentage are specifically human fibroblasts This finding has broad implications for way which these might stimulate division. It also raises question whether linkage general phenomenon.