Pharmacogenetic determinants of anti-cancer drug activity and toxicity

摘要: Cellular responses to anti-cancer agents result from the interaction between drugs, cellular targets and mechanisms of damage repair. Despite pharmacological advances in treatment cancer, clinical efficacy chemotherapy is unpredictable most patients. However, new information on genetics cancer delineates strategies by which genetic background tumour cells patients might be profiled select with improved tolerability. This article focuses application pharmacogenetics characterization differences pharmacokinetics pharmacodynamics among individuals define likelihood response reduce incidence adverse effects.