Increase in perforant path quantal size in aged F-344 rats.

摘要: The data presented here confirm and extend the evidence for fewer, but stronger, perforant path synaptic connections onto granule cells of hippocampus in old F-344 rats. animals used present report were drawn from a population that showed deficits retention spatial problem Morris water task. Using method minimal-stimulation afferents, unitary cell EPSPs found to be larger 25-month than 6- 9-month age groups. Furthermore, applying statistical methods quantal analysis, are suggest responses rats come about through an increase size. These experiments therefore individual synapses become more powerful pathway rats, this strengthening occurs implications these findings hippocampal information processing discussed.